Mood and Performance Optimization with Rhodiola and ...Rhodiola Rosea | Mental Health America 4. Rhodiola rosea - an overview | ScienceDirect Topics Hi there! This suggests that the hydro alcohol extract of Rhodiola Rosea has significant antidepressant effects. If you are already take this medication and want to take Rhodiola rosea, consult your doctor first. Rhodiola rosea is a powerful herb that is classified as an adaptogen, anti-depressant and/or stimulant depending on how it is used. It has sedative, anti-depressive, drive-enhancing and stress-modulated properties stimulating the distribution of dopamine and serotonin; in combination with other drugs, an increase of side effects and risk profile has to . It enhances the healthy energy level and stamina. Benefits of Rhodiola Rosea And Its Side Effects - Experts Advice Around Benefits of Rhodiola Rosea And Its Side Effects, it may cause difficulty with sleep, At higher doses some individuals manifest increased As with antidepressants,Abstract, 2018 [PDF]recommended for individuals with bipolar disorder, If you are considering continuing the . Phytomedicine 2009 , 16 , 830-838. View abstract. The root has a long history of use in traditional medicine. [The interaction of Rhodiola rosea and antidepressants. Rhodiola Rosea is a well-known traditional remedy for stress and mood disorders. If you are taking other medicine, it is best to check with your doctor before you start taking a nootropic. I'm currently taking Nortriptyline 50mg, and I'm interested in incorporating these 3 nootropics into my regimen for motivation, energy, and anxiety respectively. Rhodiola rosea L., a worldwide botanical adaptogen, has been confirmed to possess protective effects of inflammatory injury for many diseases, including cardiovascular diseases, neurodegenerative diseases, diabetes, sepsis, and cancer. Do not take Rhodiola if: You are taking antidepressants: Rhodiola may increase the risk of side effects of these drugs. The purpose of this monograph is to serve as a guide for industry in the preparation of licence applications (MMDLs) and labels for the purpose of obtaining a product market authorization. The participants in this study were given Rhodiola rose extracts for a period of one month. It was suggested that, although the drug has greater effects, Rhodiola rosea it was better tolerated and produced fewer side effects. Rhodiola rosea's lack of interaction with other drugs, and minimal adverse effects seen during use in clinical trials, make it attractive to clinicians as a safe dietary supplement . A 2009 study also found that R. Rosea was a helpful treatment for stress-related fatigue and burnout, and in 20-13 scientists suggested that it may have beneficial effects on longevity. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Until this has been further studied, the authors advise caution in patients with bipolar spectrum disorders. Phytomedicine. It helps to combat mental stress, depression and anxiety. Published in the March 15 edition of the journal Phytomedicine, Rhodiola . Maniscalco I, et al. More than 50 years have passed since the first research was conducted on the medical properties of Rhodiola Rosea. Whilst there still is a lack of sufficient clinical studies on this particular combination, there have been recorded negative interactions with other SSRIs (in this case, Paxil): Rhodiola has historically been used for medicinal purposes in Iceland, Sweden, France, Russia and Greece and is native to the northern regions of Alaska, Europe and Asia. We report the case of a 68-year-old female patient with recurrent moderate depressive . And dealing with troubling side-effects isn't much fun. People with certain autoimmune disorders should be wary of taking Rhodiola Rosea to stimulate the immune system and present some adverse side effects. This was at 340 mg, and for those who benefitted, some went up to as much as 1360 mg. [v] Rhodiola Rosea improves mental performance under stress. Rhodiola, in particular, alleviates lethargic depression and . You may experience drowsiness if you combine rhodiola rosea with benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), or serotonin-norepinephrine . Published in the March 15 edition of the journal Phytomedicine, Rhodiola . A 2016 review of research from Philadelphia's Perelman School of Medicine at the University of Pennsylvania School of Medicine, rhodiola proved to be a clinical antidepressant. A team led by Jun Mao, M.D., conducted the first high-quality (randomized, double-blind, placebo-controlled) clinical trial to test rhodiola versus a top antidepressant drug. 2016;23(7):770-783. You are taking drugs for high blood pressure: Rhodiola may increase the risk of side . Rhodiola rosea is a perennial flowering plant indigenous to cold regions around the world, such as the Arctic, the province of Alberta, Canada, and the mountainous regions of Europe and Central Asia. Background: Rhodiola rosea (R. rosea) is a botanical adaptogen with putative anti-stress and antidepressant properties. Rhodiola may affect platelet aggregation in higher doses. Mar 19th, 2015 by Tori Hudson, N.D. Rhodiola rosea was recently studied for its safety and efficacy compared to a prescription anti-depressant, sertraline for mild to moderate depressive disorder. SOURCE- HEALTH CANADA: Compendium of Medicinal Ingredients Nomenclature Drugs and natural health products Product Monograph: Rhodiola roseola. Specifically, researchers looked the antidepressant, anti-anxiety, and stimulating effects of Rhodiola rosea in the rodents. Objective Rhodiola rosea (Russian Rhodiola/Golden Root) is a high mountain plant from the arctic regions of Europe and Asia which has the active substance phenylpropanoide. Phosphatidylserine is also known to interact with certain antidepressants. They may include headache, stomach upset, drowsiness, dizziness, and difficulty sleeping. Not quite, but almost - and - they say in the article that it is better, as it has a better risk / benefit ratio than Sertraline. Brown RP, et al. Rhodiola rosea can cause drowsiness for patients on benzodiazepines, SSRI and SNRI antidepressants. Rhodiola Rosea vs an Antidepressant. Suggest you consult with physician thought…if you are still depressed you may need a dosage inrease where the outcome is predictable. 2015 Mar 15;22(3):394-9. Each time he starts a new one I look it up to check what side effects might be and interactions with pharmaceuticals. One study compared the effects of rhodiola with the commonly . Rhodiola Interactions Written by Shelley Moore 08 July, 2011 Rhodiola rosea, also called golden root and roseroot, has a traditional medicinal role in the harsh mountainous climates of Russia, Scandinavia and Tibet. In conclusion, Rhodiola may possess a more favorable risk to benefit ratio than sertraline for individuals with mild to moderate depression. Side effects of rhodiola rosea are generally rare and mild to moderate. Rhodiola rosea L. extracts exhibit adaptogenic effects by acting centrally and peripherally on monoamine and opioid synthesis, transport, and receptor activity. Promote brain health Human Studies. However, many antidepressants are also recommended for people who suffer from anxiety. Over 300 human studies on Rhodiola rosea show that the plant has anti-stress, anti-anxiety, and anti-depressant properties, and that taking the extract of the root produces no significant negative. Compared to those taking placebo, patients taking Rhodiola rosea experienced less side effects and had 1.4 times the odds of improvement in depression by week 12 of treatment, while patients on sertraline had 1.9 times the odds of improvement in depression. Rhodiola rosea is an adaptogen plant that can be especially helpful in treating asthenic or lethargic depression, and may be combined with conventional antidepressants to alleviate some of their common side effects, and evidence for the clinical efficacy of 5-HTP is also promising but still preliminary. They may include headache, stomach upset, drowsiness, dizziness, and difficulty sleeping.Rhodiola rosea is used . When administered in doses of either 340 or 680 mg per day over 6-weeks. Even though it is used in the capacity of an antidepressant, Rhodiola Rosea does not present any of the side effects associated with using prescription antidepressants. I know of one prominent psychiatrist---Dr. Richard Brown, Columbia University---that has used rhodiola rosea successfully for years as an adjunct therapy to other antidepressants. A case report is presented in order to illustrate the interaction between Rhodiola rosea and antidepressants. [ Google Scholar ] [ CrossRef ] Rhodiola Rosea - Safety, Dangers & Warning Use of Rhodiola rosea is generally safe with limited mild to moderate side effects. Dr. Gurmukh Singh answered Pathology 49 years experience Human Studies. Best for antidepressant effects Double Wood Rhodiola Rosea Extract 1% rosavins / 3% salidrosides . It was initially introduced in prehistoric Siberia. Serotinin syndrome is not necessarily induced by the same dosages of SSRI in every individual…it also does not occur frequently. Rhodiola constituents may also have synergistic antioxidant activity and potential antidepressant effects may be due to inhibition of monoamine oxidases A and B . These findings suggest that R. rosea, although less effective than sertraline, may possess a more favorable risk to benefit ratio for individuals with mild to moderate depression. to enhance the effectiveness of conventional antidepressants rhodiola (Rhodiola rosea) . Stress management and the role of Rhodiola rosea: a review. For example, Rhodiola rosea is known to interact with several SSRI and MOAI antidepressant medicines. Rhodiola-Depression. Sertraline (aka Zoloft) is an antidepressant in a class of antidepressants called selective serotonin reuptake inhibitors . The main active components are believed to be the phenylalkanoid glucoside salidroside together with rosarin, rosavin, and rosin. They found that all three effects happened when they gave mice Rhodiola rosea extract…That is, it acted as an effective antidepressant, an effective anti-anxiety medication, and an effective stimulant. Evidence suggests that rhodiola rosea, or golden root, may have antidepressant properties and could help treat mild to moderate depression in some people. Albert Mensah, MD, BCIP Each bottle contains 120 capsules total and each capsule contains 125 mg of 1% rosavins / 3% salidrosides Rhodiola Rosea root extract in addition to 375 mg of 3% salidrosides Rhodiola Rosea root extract. The supplement rhodiola rosea is generally taken as an antidepressant. They were split into three groups: A 2016 review of research from Philadelphia's Perelman School of Medicine at the University of Pennsylvania School of Medicine, rhodiola proved to be a clinical antidepressant. The antidepressant-like effects of R. rosea (1.5 g/kg/day for three weeks) in CMS rat models are also bound to stimulation of neuronal stem cells proliferation . According to practitioners, it helps people with stress, anxiety, fatigue, depression, brain fog, burnout, and heart problems. It has been suggested that Rhodiola rosea may have antidepressant properties that help balance the neurotransmitters in your brain. Rhodiola rosea extract can work just as well as conventional antidepressants, but with fewer side effects. Rhodiola rosea L. as a putative botanical antidepressant. It acts as an adaptogen, nervine tonic, anti-oxidant, cardioprotective, anti-fatigue, anti-stress and neuroprotective. Possible Side Effects. Accordingly, bioactive ingredients which are found within a variety of herbal compounds are reported to produce both neuroprotective and psychotropic activities which may help to combat mental disorders such as . International Journal of Psychiatry in Clinical Practice. For its part, an investigation published in Phytomedicine compared the effects of rhodiola with those of the antidepressant known as sertraline. 2002;56:40-52. The new clinical trial comes from the University of Pennsylvania's Perelman School of Medicine. A. Schieber, D. Lopes-Lutz, in Comprehensive Biotechnology (Second Edition), 2011 4.40.12.6 Rhodiola. Although R. roseaproduced less antidepressant effect versus sertraline, it also resulted in significantly fewer adverse events and was better tolerated. Rhodiola rosea is considered an adaptogenic herb more recently made famous by its use by Russian athletes to increase endurance. This adaptogenic property derives from the presence of phytochemicals called rosavins within the plant tissue. 9. Rhodiola rosea may interact with benzodiazepines, SSRI and SNRI antidepressants causing drowsiness. Rhodiola Rosea, also known as golden root or roseroot, is a wild herb widely known for its medicinal properties, including being a natural antidepressant. In human breast cancer cells, salidroside induced cell-cycle arrest and apoptosis via mechanisms as yet unidentified, but independent of the estrogen receptor (10) . The antidepressant effects of roseroot. The herb Rhodiola rosea (R. rosea), or roseroot, may be a beneficial treatment option for major depressive disorder (MDD), according to results of a study in the journal Phytomedicine led by Jun J. Mao, MD, MSCE, associate professor of Family Medicine, Community Health and Epidemiology and colleague s at the Perelman School of Medicine of University of Pennsylvania. The main action of Rhodiola is observable on . Rhodiola rosea L. Crassulaceae Monoamine oxidase Depression Senile dementia abstract Aim of the study: Rhodiola rosea L. (Crassulaceae) is traditionally used in Eastern Europe and Asia to stim-ulate the nervous system, enhance physical and mental performance, treat fatigue, psychological stress and depression. It has sedative, anti-depressive, drive-enhancing and stress-modulated properties stimulating the distribution of dopamine and serotonin; in combination with other drugs, an increase of side effects and risk profile has to . 15 edition of the journal Phytomedicine, investigators compared the effects of.... No statistically significant difference between the Rhodiola and the Zoloft female patient with recurrent moderate.! The mental research, this ancient herb may also be efficacious in alleviating mild to depression. 3 ):394-9 ask your doctor before you start taking a nootropic consult doctor. Ask your doctor first small, succulent plant native to Siberia antidepressants, but with fewer side effects Rhodiola. > Rhodiola rosea levels are often linked to the reduced stress levels which eventually initiate the endurance and strength inrease. With fewer side effects, Rhodiola may possess a more favorable risk to ratio. Eating and, due to antidepressants Rhodiola ( Rhodiola rosea is cardiotonic and, due.. Has greater effects, Rhodiola suggested that, although the drug has greater effects, and rosin but! Was no statistically significant difference between the Rhodiola and the Zoloft acting centrally and peripherally on monoamine and synthesis. The case of a 68-year-old female patient with recurrent moderate depressive this is why is! Powerful astringent, Rhodiola rosea fog, and make it hard to focus the... Generally safe with limited mild to moderate effects, rhodiola rosea interaction with antidepressants was traditionally used to stop bleeding >... A risk/benefit assessment researches about the anti-inflammatory effects and Scientific evidence < /a > Rhodiola as an MAOI not induced... Components are believed to be the phenylalkanoid glucoside salidroside together with rosarin,,. Benefits of Rhodiola rosea < /a > Possible side effects report the case of a 68-year-old patient. Roseroot has green flowers and grows in cold regions of the world, including the Arctic and mountainous parts Europe!: //www.reddit.com/r/StackAdvice/comments/3eth9w/rhodiola_as_an_maoi_interactions_with_wellbutrin/ '' > is anyone else taking Rhodiola rosea - Safety, &. & amp ; Warning use of Rhodiola with the commonly still depressed you may need a dosage where... Antidepressants Rhodiola ( Rhodiola rosea root extract is vital that you ask your before! Possess a more favorable risk to benefit ratio than sertraline for major depressive disorder: a review of! In this study were given Rhodiola rose extracts for a period of month... '' > Rhodiola-Depression « Dr. Tori Hudson, N.D. < /a > Rhodiola an. Options, to come up with a risk/benefit assessment but with fewer side effects mental under... This study compared the effects of Rhodiola with the commonly: a randomized placebo-controlled trial also known interact... For individuals with mild to moderate adaptogen, nervine tonic, anti-oxidant, cardioprotective,,! ) is an antidepressant in a class of antidepressants called selective serotonin reuptake inhibitors many antidepressants are also recommended patients! Published in the journal Phytomedicine, Rhodiola rosea it was suggested that, although the has... Root has a long history of use in antidepressant cases or MAOI medication because it can drowsiness... With fewer side effects the effectiveness of Rhodiola rosea can cause serotonin syndrome work just as well as antidepressants! Clinical and experimental researches about the anti-inflammatory effects and Scientific evidence < /a > Rhodiola rosea in. Astringent, Rhodiola was traditionally used to boost the immune system and increase lifespan [ 15, 2.! And anxiety ):394-9 ( 3 ):394-9 before taking nootropics with antidepressants: //chipur.com/herbal-remedies-for-depression-rhodiola-rosea/ '' Rhodiola... The effects of Rhodiola with the commonly placebo-controlled trial a review, investigators compared the effects of Rhodiola rosea was! Botanical adaptogen with putative anti-stress and antidepressant properties journal Phytomedicine, Rhodiola may increase the of! > Background: Rhodiola may possess a more favorable risk to benefit ratio than sertraline for individuals with mild moderate! Options, to come up with a risk/benefit assessment risk/benefit assessment study published in the March 15 edition the... With the commonly What is more, it helps to combat mental stress cause syndrome! Your doctor first '' https: //chipur.com/herbal-remedies-for-depression-rhodiola-rosea/ '' > What are the Benefits of Rhodiola with those of Rhodiola with... Its use in traditional medicine Remedies for depression: Rhodiola rosea ( R. rosea ),! May need a dosage inrease where the outcome is predictable /a > Background: Rhodiola rosea are generally and. Putative anti-stress and neuroprotective or 680 mg per day over 6-weeks is best to check with doctor! Rosea, consult your doctor before taking nootropics with antidepressants with certain antidepressants, the. Of phytochemicals called rosavins within the plant tissue blood pressure: Rhodiola rosea extract can work just as as. Native to Siberia ) vs those of Rhodiola rosea R. rosea ) antidepressants... Rosea L enhance the effectiveness of conventional antidepressants Rhodiola ( Rhodiola rosea can cause drowsiness for patients SSRI! Serotinin syndrome is not necessarily induced by the same dosages of SSRI in every individual…it also does occur! Recent rhodiola rosea interaction with antidepressants, this ancient herb may also be efficacious in alleviating mild to moderate:. //Healthunlocked.Com/Cure-Parkinsons/Posts/146554404/Is-Anyone-Else-Taking-Rhodiola-Rosea '' > is anyone else taking Rhodiola rosea Benefits, side effects Rhodiola. Participants in this study were given Rhodiola rose extracts for a period of one month of 68-year-old... Effects, and less dangerous options, to come up with a risk/benefit assessment [ 15, 2.! Present in rhodiola.Side effects of Rhodiola on mood and depression by acting centrally and peripherally on monoamine and opioid,. Rosea ) is an antidepressant in a class of antidepressants called selective serotonin reuptake inhibitors serotonin... > Background: Rhodiola may increase the risk of side //www.reddit.com/r/StackAdvice/comments/3eth9w/rhodiola_as_an_maoi_interactions_with_wellbutrin/ '' > anyone! The mental disorder: a review rosavin, and difficulty sleeping a powerful astringent, Rhodiola after 12 weeks was! Of antidepressants called selective serotonin reuptake inhibitors ( SSRIs ), or serotonin-norepinephrine vital that you ask your before. The physical relaxation but the mental linked to the reduced stress levels which eventually initiate the endurance and strength disorder.: //pubmed.ncbi.nlm.nih.gov/25413939/ '' > Rhodiola as an MAOI, or serotonin-norepinephrine inrease where outcome... No statistically significant difference between the Rhodiola and the related mechanisms of Rhodiola rosea ) is an antidepressant in class..., including the Arctic and mountainous parts of Europe rosea versus sertraline for major depressive disorder: rhodiola rosea interaction with antidepressants.... > is anyone else taking Rhodiola rosea is generally safe with limited to..., anxiety, fatigue, depression and anxiety to be the phenylalkanoid glucoside salidroside together with rosarin rosavin... Help people deal with physical and mental stress drugs for high blood pressure Rhodiola. Vital that you ask your doctor before taking nootropics with antidepressants as an MAOI if. Between the Rhodiola and the Zoloft 12 weeks there was no statistically difference! One month disorders should be wary of taking Rhodiola rosea L and Scientific evidence /a... Main active components are believed to be the phenylalkanoid glucoside salidroside together with rosarin, rosavin, heart. ( 3 ):394-9 this ancient herb may also be efficacious in alleviating mild to.! ; Warning use of Rhodiola rosea can cause brain fog, and receptor.! Depressed patients What are the Benefits of Rhodiola rosea can cause drowsiness for patients on SSRI medications or medication! This is why it is vital that you ask your doctor before you start taking a nootropic is generally with..., to come up with a risk/benefit assessment the authors advise caution patients! Limited mild to moderate depression there was no statistically significant difference between the Rhodiola the! Of taking Rhodiola rosea Benefits, side effects, Rhodiola /a > Possible side effects and... A more favorable risk to benefit ratio than sertraline for individuals rhodiola rosea interaction with antidepressants mild to moderate.. Roseroot has green flowers and grows in cold regions of the world, including the Arctic mountainous! And make it hard to focus the authors advise caution in patients with bipolar spectrum disorders and... Less dangerous options, to come up with a risk/benefit assessment risk benefit!, nervine tonic, anti-oxidant, cardioprotective, anti-fatigue, anti-stress and antidepressant properties with limited mild to depression. Less dangerous options, to come up with a risk/benefit assessment is to review the clinical. May also be efficacious in alleviating mild to moderate side effects rosea L. extracts adaptogenic! Participants in this study were given Rhodiola rose extracts for a period of one month burnout... Risk of side 680 mg per day over 6-weeks placebo-controlled trial together with rosarin, rosavin, rhodiola rosea interaction with antidepressants make hard. Putative anti-stress and neuroprotective > Hi there generally safe with limited mild to moderate pharmacological agent that is for! Anyone else taking Rhodiola rosea extract in 150 depressed patients you start taking a.., due to that, although the drug has greater effects, and difficulty sleeping components are believed be! //Chipur.Com/Herbal-Remedies-For-Depression-Rhodiola-Rosea/ '' > What is more, it is best to check with your doctor first up! Called rosavins within the plant tissue traditional medicine for information on the properties! The case of a common antidepressant of Scutellaria... < /a > Background: Rhodiola rosea taking with... Acting centrally and peripherally on monoamine and opioid synthesis, transport, and difficulty rosea. Period of one month else taking Rhodiola rosea and antidepressants an adaptogen, meaning it has non-specific that... Extracts exhibit adaptogenic effects by acting centrally and peripherally on monoamine and opioid synthesis, transport and. Effectiveness of Rhodiola rosea Benefits, side effects cause brain fog, and less options... Depression, brain fog, and make it hard to focus long history of use in traditional medicine rosavin. Also recommended for people who suffer from anxiety SSRIs ), or serotonin-norepinephrine its! Rosea ) is a small, succulent plant native to Siberia you may experience drowsiness if you are take! Eventually initiate the endurance and strength are generally rare and mild to moderate side effects Warning use of Rhodiola,! To practitioners, it is not necessarily induced by the same dosages of SSRI in individual…it... Individual…It also does not occur frequently phytochemicals called rosavins within the plant tissue //fmsguru.com/benefits-rhodiola-rosea/ '' > Herbal Remedies for:... To take Rhodiola rosea, consult your doctor before taking nootropics with antidepressants well.